A curve model for association of serum homocysteine with carotid artery hemodynamics

Zewei Wu,Yufeng Wen,Mengxue Liu,Haibo Li,Yu Zhu,Huiping Zhang,Tiantian Ren

doi:10.4314/tjpr.v16i8.31

Zewei Wu, Yufeng Wen + Show 5 more

Open Access

https://doi.org/10.4314/tjpr.v16i8.31

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Abstract

Purpose: To investigate the correlation between carotid artery hemodynamics and serum homocysteine. Methods: A total of 894 participants made up of 439 male (49.11 %) and 455 female (50.89 %) from Ma’anshan, China, enrolled in the cross-sectional study. Data collection included demographics, blood sample and carotid ultrasonography. Piecewise linear regression analysis was used to analyze the relationship between serum homocysteine and carotid artery hemodynamics. Results: Homocysteine (Hcy) levels were divided into four groups by quartiles. The populations of the groups were 226, 220, 222, 226; and their mean ages were 56.52 ± 10.49, 62.27 ± 10.06, 63.42 ± 9.81 and 65.38 ± 10.56 years, respectively. After adjustment for blood biochemical and demographics factors, U-shaped and S-shaped curves were as observed between Hcy and carotid artery hemodynamics. The adjusted regression analysis showed that the threshold values of Hcy with end diastolic velocity (EDV) of right common carotid artery (CCA) were 12.50 and 19.00, while for the EDV of right internal carotid artery (ICA), the values were 11.50 and 22.00. U-shaped curves were observed between Hcy and peak systolic velocity (PSV) of left CCA, EDV of left CCA, PSV of left ICA and EDV of left ICA. The threshold values of Hcy with PSV of left CCA, EDV of left CCA, PSV of left ICA and EDV of left ICA were 14.00, 14.00, 14.00 and 13.50, respectively. Conclusion: These results indicate that a significant correlation exists between homocysteine at different concentrations and carotid artery hemodynamics. Keywords: Homocysteine, Hemodynamics, End diastolic velocity, Peak systolic velocity

Highlights

Cardiovascular disease (CVD) is a main cause of death across the globe, resulting in more than 17.3 million deaths in 2013, and is projected to result in the death of more than 23.6 million people by 2030 [1]
Peak systolic velocity (PSV) ratio of common carotid artery (CCA) was positively associated with high-grade common carotid stenosis [8]
Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), fasting plasma glucose (FPG) and Hcy were determined with automated biochemical analyzer (DPP-800, Roche, Germany) in Ma’anshan People’s Hospital

Summary

INTRODUCTION

Cardiovascular disease (CVD) is a main cause of death across the globe, resulting in more than 17.3 million deaths in 2013, and is projected to result in the death of more than 23.6 million people by 2030 [1]. Peak systolic velocity (PSV) ratio of CCA was positively associated with high-grade common carotid stenosis [8]. A recent study showed that Hcy was positively correlated with carotid intima-media thickness (IMT) in adolescent hypertension [9]. Results of a cross-sectional study showed that increased Hcy was associated with advanced carotid plaque in males [10]. Despite the fact that Hcy and hemodynamics are associated with IMT and carotid plaque, their exact inter-relationship is yet to be investigated. The relationship between Hcy and other hemodynamic parameters such as PSV and end diastolic velocity (EDV) is not yet understood. The current research is a cross-sectional study to investigate whether there is an association between serum Hcy and PSV and EDV of carotid artery

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CONCLUSION

Conflict of Interest