A cularine-type isoquinoline alkaloid from the root part of Cissampelos pareira

Abstract

One cularine-type alkaloid (1) was isolated along with two known compounds (2 and 3) from the roots of Cissampelos pareira. The isolated compound’s chemical structures were elucidated by 1 D and 2 D NMR spectroscopy and mass spectrometry analysis. This is the first report on the cularine-type alkaloid from the genus Cissampelos. Compound (2) was reported for the first time from C. pareira. In silico molecular docking analysis showed various interactions of compounds with the active site residue of GABAA receptor, which could help to understand their putative mode of action in neurodevelopmental malfunctions and in anaesthesia.