Abstract
Development of an economic and commercial manufacturing process for an anti-psychotic drug substance clozapine with an alternative key starting material (2-chloro benzoic acid) in the place of literature reported key starting material Anthranilic acid. To avoid narcotic key starting materials usage in drug substances the author invented a commercially available raw material 2-chlorobenzoic acid, which reacts with another key starting material 4-chloro-1, 2-diamino benzene. This reaction proceeds through Ullman reaction to produce multi scale level Clozapine which quality meets the ICH requirements.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have