Abstract
Many proteins are difficult to target with drugs because their primary function is to participate in protein-protein interactions (PPIs) and protein-nucleic acid interactions (PNIs) through flat interfaces that are less conducive to small molecule binding. These interactions are found in many viral proteins that interact with host factors and viral nucleic acids in order to evade the host immune system. We focused our study on viral protein 35 (VP35), from the highly lethal Ebola virus. VP35 plays essential roles in Ebola's replication cycle, including binding the viral RNA genome to block a host's innate immunity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
