Abstract
A new target design is described for the production of fluorine-18 in the chemical form of fluoride. The target is conical in shape with a cooling block extending radially. The target material is oxygen-18 enriched carbon dioxide gas which is frozen onto the cooled surface. The rear of the cone and cooling block are surrounded by a bath of liquid nitrogen. The use of C 18O 2 in place of H 2 18O as a target material increases the recovery efficiency and thus reduces the amount lost in each irradiation. After irradiation, 99% of the enriched gas was recovered by warming the target and cryogenically transferring the gas into a storage bubl. After transfer, the fluoride was rinsed from the target surface with water. The production from this target was 90–140 mCi/μA at saturation. The chemical form of fluoride has been verified by ion chromatography and the reactivity has been verified by use in the synthesis of FDG. This target is superior to the oxygen-18 enriched water target in the efficiency of recovery of the enriched target material which in turn reduces the cost of each irradiation.
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