Abstract
BackgroundEnteric fever is one of the common infectious diseases of humans. The objectives of this study were to:1) estimate the prevalence of enteric fever among febrile patients visiting Ambo hospital; 2) comparison of Widal test and stool culture;3) evaluation of the antimicrobial susceptibility of isolates; and 4) assess potential risk factors to acquire enteric fever infection.MethodsBlood and stool samples were collected from 372 febrile patients with symptoms clinically similar to enteric fever. Widal test was used for testing sera while stool culturing and bacterial identification was done using WHO standard methods. Susceptibility testing was done using Kirby-Bauer disc diffusion method. Chi-Square test and Logistic Regression analysis were used to analyze the data.ResultsThe apparent and true prevalence of enteric fever were 56.2% (95% confidence interval [CI]: 50.97–61.29%) and 57.52% (95% CI: 52.3–62.6%) respectively, while, the culture prevalence was 2.7% (95% CI: 1.30–4.89%). Isolation rates of S. Typhi and S. Paratyphi were 0.8% (95% CI: 0.17–2.34%) and 1.9% (95% CI: 0.76–3.84%) respectively. The isolates showed 100% resistance to amoxicillin, bacitracin, erythromycin, 80%resistance to cefotaxime and streptomycin and 20% for chloramphenicol. The sensitivity, specificity, positive and negative predictive values of Widal test was 80.0, 44.5, 3.8 and 98.8% respectively. Multivariable logistic regression analysis revealed that age (adjusted odds ratio [aOR] = 2.45; 95% CI: 1.38–4.37; P = 0.002), religion (aOR = 15.57, 95% CI: 3.01–80.64; P = 0.001), level of education (aOR = 2.60, 95% CI: 1.27–5.28; P = 0.009), source of water (aOR = 2.20, 95% CI: 1.21–3.98; P = 0.009), raw milk (aOR =2.19, 95% CI:1.16–4.16; P = 0.016) and raw meat consumption (aOR = 1.80, 95% CI: 1.07–3.01; P = 0.026) are the predictors of enteric fever seropositivity.ConclusionsPatients were wrongly diagnosed and treated for enteric fever by Widal test. Therefore, rapid tests with better sensitivity and specificity are needed for the diagnosis of enteric fever. Provision of safe water and health education are vital to bring behavioral change towards raw food consumption.
Highlights
Enteric fever is one of the common infectious diseases of humans
Multivariable logistic regression analysis revealed that age, religion, level of education, source of water, raw milk and raw meat consumption are the predictors of enteric fever seropositivity
Rapid tests with better sensitivity and specificity are needed for the diagnosis of enteric fever
Summary
Enteric fever is one of the common infectious diseases of humans. The objectives of this study were to:1) estimate the prevalence of enteric fever among febrile patients visiting Ambo hospital; 2) comparison of Widal test and stool culture;3) evaluation of the antimicrobial susceptibility of isolates; and 4) assess potential risk factors to acquire enteric fever infection. Typhoid fever is an acute systemic febrile illness caused by the bacterium Salmonella enterica serovar Typhi. Salmonella enterica serovars Paratyphi A, B, and C cause the clinically similar condition, paratyphoid fever [1, 2]. Typhoid and paratyphoid fevers are collectively known as enteric fevers [1]. While both diseases share clinical features, paratyphoid fever tends to have a more benign course of illness [3]. Enteric fever commonly presents with nonspecific clinical features such as fever, flu-like symptoms with chills, a dull frontal headache, malaise, anorexia, poorly localized abdominal discomfort, a dry cough and myalgia, nausea, vomiting, constipation, and diarrhea [1, 5, 6] which are indistinguishable from other causes of fever such as malaria
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