Abstract
BackgroundPrevious studies have just found skeletal muscle mass decline is associated with arterial stiffness, but it is unclear whether muscle strength and physical performance as important compositions of sarcopenia are associated with arterial stiffness. The aim of this study was to investigate the relationship between sarcopenia, the components of sarcopenia and arterial stiffness among elderly in the community.MethodsThis study enrolled 450 elderly people who received general medical examinations in Tianjin First Center Hospital. Each of the subjects was greater than 65 years old, including 266 male and 184 female subjects. Based on the diagnostic criteria for sarcopenia in older people developed by the Asian Working Group for Sarcopenia (AWGS), 89 subjects were separated into the sarcopenia group. The living habits, disease status, general status and laboratory examinations of all subjects were collected. The body composition (including appendicular skeletal muscle mass and visceral fat area (VFA) of each participant) was measured by bioimpedance analysis. HS, usual gait speed (GS), and brachial ankle pulse wave velocity (baPWV) were measured.ResultsSarcopenia subjects had higher baPWV, nutrition risk and lower appendicular skeletal muscle index (ASMI), Handgrip strength (HS), GS, body mass index (BMI), triacylglycerol (TG), serum albumin (ALB) and creatinine (Cr) than did non-sarcopenia subjects; Sarcopenia subjects also had higher visceral fat area (VFA) than did non-sarcopenia subjects (p < 0.05). ASMI and HS were negatively associated with baPWV (t = − 5.807, p = 0.000 and t = − 3.085, p = 0.002), but the relationship between baPWV and GS was not statistically significant (t = − 0.862, p = 0.389) by multivariable linear regression. After adjusting for confounders, a multivariate logistic regression analysis revealed that sarcopenia was related with age, BMI, sports and baPWV in community dwelling elderly.ConclusionsASMI and HS were negatively associated with baPWV in community dwelling elderly in China; and baPWV was a risk factor of sarcopenia.
Highlights
Previous studies have just found skeletal muscle mass decline is associated with arterial stiffness, but it is unclear whether muscle strength and physical performance as important compositions of sarcopenia are associated with arterial stiffness
The previous studies did not involve muscle strength and physical performance [5, 6]. It is unclear whether sarcopenia and the important compositions of sarcopenia-muscle strength and physical performance are associated with arterial stiffness
BaPWV was taken as the dependent variable, appendicular skeletal muscle index (ASMI), Handgrip strength (HS) and gait speed (GS) were tested simultaneously as independent variables and models were adjusted for sex, age, body mass index (BMI), visceral fat area (VFA), hypertension, diabetes, cardiac, smoking, sports participation, Mini-nutritional Assessment short-form (MNA-SF), TG, low-density lipoprotein cholesterol (LDL-C), hemoglobin A1C (HbA1C), Hb, ALB and Cr
Summary
Previous studies have just found skeletal muscle mass decline is associated with arterial stiffness, but it is unclear whether muscle strength and physical performance as important compositions of sarcopenia are associated with arterial stiffness. Sarcopenia is determined by muscle mass, and by muscle strength and physical performance. The previous studies did not involve muscle strength and physical performance [5, 6] It is unclear whether sarcopenia (according to the diagnostic criteria for sarcopenia by AWGS in 2014 [7]) and the important compositions of sarcopenia-muscle strength and physical performance are associated with arterial stiffness. The present study was designed to investigate the relationship between sarcopenia, the components of sarcopenia and arterial stiffness according to the Consensus Report of the Asian Working Group in 2014 in Chinese community dwelling elderly
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