A CROSS-SECTIONAL STUDY OF SERUM OSTEOCALCIN LEVEL ASSOCIATED WITH PERIPHERAL ARTERIAL STIFFNESS BY BRACHIAL-ANKLE PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS

Abstract

Objective: Brachial-ankle pulse wave velocity (baPWV) is recognized as an independent risk factor for cardiovascular events, cardiovascular mortality, and all-cause mortality. Osteocalcin (OC) is associated with vascular function. The aim of this study was to evaluate the relationship between serum OC levels and peripheral arterial stiffness (PAS) in hypertensive patients measuring by baPWV. Design and method: Fasting blood samples were obtained from 120 hypertensive patients. Peripheral arterial stiffness was measured by baPWV device. Serum total OC levels were measured using a commercial enzyme-linked immunosorbent assay kit. Left or right brachial-ankle pulse wave velocity (baPWV) > 18.0 m/s defined the PAS group. Results: Twenty-four patients (20.0%) were included in the PAS group in hypertensive patients. Hypertensive patients with PAS had a significantly higher percentage of diabetes (P = 0.010), older age (P = 0.011), higher systolic blood pressure (P = 0.019), serum fasting glucose (P = 0.003), blood urea nitrogen (P = 0.024), creatinine (P = 0.004), C-reactive protein (P = 0.007), and OC level (P = 0.002), while lower estimated glomerular filtration rate (P = 0.004) than those without PAS. After multivariable logistic regression analysis, serum OC level (Odds ratio [OR]: 1.797, 95% confidence interval (CI): 1.077–3.000, P = 0.025), and age (OR: 1.076, 95% CI: 1.004–1.153, P = 0.037) are independently associated with PAS in hypertensive patients. Conclusions: Serum OC levels and older age are positively associated with PAS in hypertensive patients.