Abstract
BackgroundNausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), respectively, as defined by Rome IV criteria; and, 2) relationships between nausea and mucosal inflammation as defined by antral and duodenal eosinophil and mast cell densities. A secondary aim was to assess relationships between nausea and other gastrointestinal symptoms, non-gastrointestinal somatic symptoms, and psychological dysfunction.MethodsRecords from patients with pain associated functional gastrointestinal disorders were retrospectively reviewed for gastrointestinal and somatic symptoms and anxiety, depression, and somatizations scores as assessed by the Behavior Assessment System for Children (BASC-2). In addition, previous gastric and mucosal biopsies were assessed for mast cell and eosinophil densities, respectively.Results250 patients, ages 8 to 17 years, were assessed. Nausea was reported by 78% and was equally prevalent in those with FD alone, those with IBS alone, and those with both FD and IBS. Nausea was associated with increased mean (21.4 vs. 17.5) and peak (26.2 vs. 22.9) duodenal mast cell densities as compared those without nausea. Nausea was also associated with a wide variety of individual gastrointestinal symptoms, as well as headaches, fatigue, and dizziness. Lastly, nausea was associated with elevated self-report scores for anxiety (55.2 vs. 50.0), depression (50.2 vs. 46.1), and somatization (70.3 vs. 61.8).ConclusionsNausea is common in children and adolescents with pain-associated FGIDs as defined by Rome IV and is not unique to either FD or IBS. Nausea is associated with increased mucosal mast cell density, non-gastrointestinal somatic symptoms, and psychologic dysfunction.
Highlights
Nausea is a common symptom in youth with chronic abdominal pain
One possible mechanism would be mucosal inflammation which has been implicated in functional dyspepsia (FD) and irritable bowel syndrome (IBS) but unstudied in relation to nausea
Rome IV criteria for FD were fulfilled by 86%, IBS criteria were fulfilled by 58%, and both FD and IBS criteria were fulfilled by 50%
Summary
The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), respectively, as defined by Rome IV criteria; and, 2) relationships between nausea and mucosal inflammation as defined by antral and duodenal eosinophil and mast cell densities. For children who fulfill Rome III criteria for a pain-associated functional gastrointestinal disorder (FGID), the prevalence rate is even higher (36%) [1]. This makes sense, as nausea tends to be associated with other gastrointestinal symptoms, including worse abdominal pain [2]. Increased eosinophil and mast cell degranulation has been demonstrated in both adults and children with FD, further implicating these two cells in this condition [9,10,11,12]
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