Abstract
A variety of functionalised biaryls were synthesised on the 20–30 mmol scale by using Knochel type organozinc reagents (organozinc reagents prepared from aryl halides, Zn powder and LiCl) catalysed by PEPPSI (a pyridine enhanced palladium catalyst). The protocol enabled the Negishi reactions to proceed in a smooth, rapid and mild way to give the corresponding products in excellent yields (80 ~ 96%). Sensitive functional groups, such as CN and COOEt groups, were tolerated in the coupling reaction.
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