Abstract

In the past twenty years, great advances in medicine have occured in our understanding of the glands of internal secretion so that now the accumulation of facts about many of these glands surpasses our understanding of the functions of most other organs of the body. During this period, there has accumulated not only a great mass of physiological knowledge but also brilliant chemical successes which have resulted in the isolation, purification, and even crystallization of many active principles. This work is giving to the clinicians their most powerful therapeutic agents, yet the advances in clinical medicine are seriously lagging behind those in chemistry and physiology. This is somewhat surprising because the natural occurrence of endocrine abnormalities in man offers excellent opportunities for serious study, not only of their subtler functions and interrelations, but also of the effects of substitution therapy. New tests of functional activities and greater knowledge of interrelationships are most sore...

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