A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives

Abstract

Pyrazolone is a well-known influential synthon for the synthesis of many molecules which hold remarkable potential in the advancement of functional materials, coordination chemistry, and pharmaceutical chemistry. Taking the advantage of diversity as well as multiple active sites of starting materials, a number of effective methods for synthesizing different pyrazolone compounds have been effectively established over the last few years. The chemistry of pyrazolone derivatives have attracted interests due to their diverse pharmacological functions such as analgesic, anti-inflammatory, anti-cancer, antibacterial, antifungal, anti-oxidant, anti-diabetic, anti-viral, anti-proliferative and many other biological activities. This review article provides an overview of this field, with the aim of highlighting the remarkable achievements that have been made with the multiple reaction sites of different pyrazolone synthons and the synthetic strategies for existing and novel pyrazolone derivatives. In addition, chemical synthetic schemes, important mechanisms, structure activity relationships (SAR) and promising biological investigations relating to the corresponding products are also discussed.