Abstract
For the past several years, workers concerned with the development of diagnostic tests have observed that a more intense color is obtained when diphenylamine reacts with serum from patients with rheumatic fever, 7 nonspecific inflammations, malignant neoplasms, rheumatoid arthritis, 6 typhoid fever, hepatic lesions, and leukemia, than with serum from healthy persons. These reports indicate that the diphenylamine (DPA) reaction is more likely to be a response to generalized insult than to any specific disease state. In view of the report that the DPA reaction could be used as a diagnostic test for malignancy, it became necessary to re-evaluate the reaction in order to ascertain conditions for specificity, if any exist.
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