Abstract
Although various treatment programs have been introduced for the medical management of calcium urolithiasis, their therapeutic efficacy has been difficult to appraise critically, because of failure to define clearly indications for treatment, limited double-blind clinical trials and over-reliance on retrospective stone history. However, recent progress concerning pathogenesis of stone formation has provided an improved understanding of mechanism of drug action, and of indications for treatment. Moreover, some objective data have been gathered supporting clinical efficacy of certain treatment regimens, despite continued problems in initiation of controlled (double-blind) clinical studies.
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