Abstract
Three experimental methods related to adrenergic beta-blocking and anti-arrhythmic agents were compared. The appearance of aconitine arrhythmias in rats was delayed by classical and new anti-arrhythmic drugs, and by two adrenergic alpha-blocking agents, yohimbine and phentolamine. Ventricular fibrillation caused by chloroform inhalation in mice was blocked by anti-arrhythmic drugs and by yohimbine and phentolamine. Adrenergic beta-blocking agents antagonized the bronchodilation induced by isoprenaline in the guinea-pig. This property was not shared by classical anti-arrhythmic drugs, nor by the two alpha-blockers. The use of the three methods is suggested for evaluating new anti-arrhythmic agents, which should preferably lack adrenergic beta-blocking properties, to avoid inhibition of the sympathetic control of the heart and possibly bronchoconstriction.
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