Abstract
The intestinal proliferon model postulates a highly synchronized, intimate relationship between the epithelial cells and the underlying connective tissue elements. This model allows certain predictions to be made concerning the distribution in space and time of proliferative activity, migratory behaviour and the distribution of cell death in the epithelial cells and the cells of the lamina propria. An extensive investigation of the pericryptal fibroblast sheath, which is a layer of fibroblasts which immediately surrounds the crypt and would be a major component of any putative proliferon system, has revealed that none of these predictions is borne out. It has, therefore, been concluded that the proliferon model does not apply, at least to the murine small intestine and colon. An alternative model is proposed for the life cycle of the pericryptal fibroblast.
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