A Critical Approach in the Analysis of lncRNA Characteristics for Cancer Therapy

Abstract

Long noncoding RNAs (lncRNAs) play a major role in cancer due to mutations in the protein-coding genes. There is a strong relationship between the different lncRNAs with different types of cancers as observed by the analyses of the genomes of organisms and their possible associations in different biochemical pathways. The genome-wide association studies have been conducted on different tumor samples obtained from cancer patients. It has been observed that change in the patterns of expressions of lncRNAs as well as their mutation profiling would shed light on the mode of tumor onset. This would lead to the formations of various cancer tumors and metastasis. All these observations would make lncRNAs a special class of cancer biomarkers. It is known that the lncRNAs have their capacities to exhibit tumor-suppressive as well as tumor-causing (oncogenic) functions. The lncRNAs are expressed throughout the genomes in a number of different tissues and have their characteristic patterns of expressions in the tissues. The lncRNAs have become important targets in the diagnosis and treatment of different types of cancers. In this chapter, we tried to explore the roles and association of various lncRNAs in different types of cancers and discussed their potential implications in cancer diagnosis and therapy with special emphasis on ROS.KeywordslncRNAROSBiomarkersCancer diagnosis