Abstract
IntroductionHip fracture rates in Botswana were used to create a FRAX® model for fracture risk assessment.ObjectiveThis paper describes the development and characteristics of a country-specific FRAX model for Botswana.MethodsAge-specific and sex-specific incidence of hip fracture and national mortality rates was incorporated into a FRAX model for Botswana. Ten-year fracture probabilities were compared with those from African countries having a FRAX model and African Americans from the USA.ResultsThe probabilities of hip fracture and major osteoporotic fracture were low compared with those from South Africa (Black and Coloured) and US Blacks. Probabilities were marginally higher than for Tunisia.ConclusionThe creation of a FRAX model is expected to help guide decisions about the prevention and treatment of fragility fractures in Botswana.
Highlights
Hip fracture rates in Botswana were used to create a FRAX® model for fracture risk assessment
For other major osteoporotic fractures, it was assumed that the age-specific and sex-specific ratios of these fractures to hip fracture risk found in Sweden were comparable to those in Botswana
The 10-year probabilities of major osteoporotic fracture and hip fracture in Botswana and other African countries are shown in Table 1 in women with a prior fracture by age
Summary
Hip fracture rates in Botswana were used to create a FRAX® model for fracture risk assessment. Ten-year fracture probabilities were compared with those from African countries having a FRAX model and African Americans from the USA. Results The probabilities of hip fracture and major osteoporotic fracture were low compared with those from South Africa (Black and Coloured) and US Blacks. The output of FRAX comprises the 10-year probability of major osteoporotic fracture (hip, spine, distal forearm or proximal humerus) or hip fracture alone. This probability is in turn dependent upon the risk of fracture and the competing risk of death, both of which vary from country to country [3]. FRAX models are only available for Tunisia, Morocco and South Africa. This paper describes the synthesis of a country-specific FRAX model for Botswana
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