A correlative study of serum uric acid and serum malondialdehyde level in early essential hypertension

Abstract

Background: Hypertension (HT) posing a major public health challenge to the universe in socioeconomic and epidemiological transition. Hyperuricemia in HT is coupled with augmented cardiovascular morbidity and mortality. It also predates the development of HT and suggests that it is not simply a consequence of HT per se. Increased urate level along with greater production of oxygen-free radical and augmented oxidative stress may contribute to progression of HT. Aims and Objectives: This study aims to assess the correlation between serum uric acid (SUA), serum malondialdehyde S. MDA) level, and blood pressure in early essential HT. Materials and Methods: In this cross-sectional study, after applying inclusion and exclusion criteria, 200 subjects were divided into three groups: 50 subjects as control group, 75 in prehypertensive group, and 75 in hypertensive group. SUA and S. MDA level were estimated in all subjects. Data were analyzed by appropriate statistical methods. Results: A significant and positive correlation was observed between SUA and S. MDA level in HT group. Both parameters were correlated positively and significantly with systolic blood pressure (SBP), but not with diastolic blood pressure (DBP) in hypertensive individuals. Conclusion: An elevated SUA level is predictive for the evolution of both HT and coronary artery disease. Hyperuricemia plays a role in the formation of free radicals and oxidative stress through increased lipid oxidation. Furthermore, positive correlation with SBP further established its potential role in the etiopathogenesis of essential HT.