A correlation study of coronary computed tomography angiography and serum soluble E-selectin in the asymptomatic population with low-medium CHO risk

Abstract

Objective To examine the predictive value of serum soluble E-selectin (sE-selectin) levels for high risk plaques as detected by coronary computed tomography angiography (CCTA). Methods This was a cross-sectional study. CCTA was performed for each patient. Serum levels of sE-Selectin, sVCAM-1, sICAM-1 and sP-Selectin were measured by flow fluorescence immunomicrobead assay (FFIA). ROC curve and multivariate analysis were used to determine the predictive value for the presence of high risk plaques. Results The high risk plaques group showed higher sICAM-1 and sE-selectin levels. The multivariate Logistic analysis showed that male (OR=2.131, P=0.019), old age (OR=1.053, P=0.002), hyperlipidemia (OR=1.960, P=0.022), high level of apoB (OR=2.896, P=0.004) and high level of sE-Selectin(OR=1.975, P=0.008) were independently associated with the presence of high risk plaques. The AUC of the multivariate model for high risk plaques was 0.722.The sensitivity, specificity, the positive predictive value and the negative predictive value were 55.3%, 78.3%, 71.8% and 64.4% respectively. Conclusions High sE-selectin levels were associated with the presence of high risk plaques in asymptomatic populations at low to intermediate Framingham risk. sE-selectin can play an important role in plaque screening, as detected by coronary CTA.(Chin J Lab Med, 2018, 41: 430-435) Key words: Plaque, atherosclerotic; Coronary artery disease; Coronary angiography; Tomography, X-ray computed; E-Selectin; Risk factors; ROC curve; Sensitivity and specificity