A Correlation of the Histologic Changes and Clinical Symptoms in Irradiated Hodgkin's Disease and Lymphoblastoma Lymph Nodes

Abstract

Introduction THERE has been such extensive, and at times confusing, discussion of the etiology and genetic relationship of Hodgkin's disease, lymphosarcoma and the leukemias, that it is necessary for anyone presenting a paper on the subject to define his own views. There is no question but that a typical Hodgkin's disease lymph node presents a characteristic histologic picture. Typical lymphosarcomas also constitute a pathologic entity. In lymphatic leukemia, the involved lymph nodes are practically identical in structure with lymphosarcoma, but in the former, the blood picture characterizes the condition. The infectious nature of Hodgkin's disease, especially in regard to tuberculosis, has not yet been conclusively demonstrated. Lymphosarcoma and lymphatic leukemia are considered true neoplastic diseases. There are, however, instances in which a histologic differentiation of Hodgkin's disease from lymphosarcoma or leukemias is impossible, even by the most expert pathologists. Warthin (1) cited such cases...