Abstract
The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products. These included a new bromopyrrole, 4′-((3,4,5-tribromo-1H-pyrrol-2-yl)methyl)phenol (1) and five new korormicins G–K (2–6). Also isolated was the known inducer of coral larval metamorphosis, tetrabromopyrrole (TBP), five known korormicins (A–E, previously named 1, 1a–c and 3) and bromoalterochromide A (BAC-A). Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The antibacterial, antifungal and antiprotozoal potential of 1–6, TBP and BAC-A was assessed. Compounds 1–6 showed antibacterial activity while BAC-A exhibited antiprotozoal properties against Tetrahymena pyriformis. TBP was found to have broad-spectrum activity against all bacteria, the protozoan and the fungus Candida albicans.
Highlights
In the marine environment chemical signals play critical ecological roles at many organizational levels [1]
Yoshikawa et al reported the isolation and structural elucidation of six korormicins [5,11]. We propose that these korormicins be recognised for nomenclature purposes as korormicins A–F respectively, compound 2 is named korormicin G
Aliquots (20 μL) of fractions and compounds were evaporated on filter paper discs (d = 6 mm, Bio-Rad, Sydney, Australia) and placed on petri dishes containing Marine Agar or LB agar depending on the target strain with solvent as the negative control
Summary
In the marine environment chemical signals play critical ecological roles at many organizational levels [1]. H-pyrrol-2-yl)methyl)phenol (1) and five new korormicins G–K (2–6) along with the known coral larval metamorphosis cue, TBP [3,4], five known korormicins (A–E, previously named 1, 1a–c and 3) [5,11,12] and bromoalterochromide A (BAC-A) [13] are provided. Their antimicrobial, antifungal and antiprotozoal activities are described
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