A copper- and amine-free sonogashira reaction catalyzed by a supported bis(oxime palladacycle) on magnetized SBA-15

Abstract

The recently reported magnetic catalyst, Fe3O4@SBA-bis(oxime palladacycle), was incorporated in the Sonogashira reaction. The potential catalytic activity of the catalyst was evaluated by optimizing the reaction conditions. It was discovered that using dimethylsulfoxide (DMSO) as a solvent, a catalyst loading of 0.25 mol% palladium, Cs2CO3 as a base, and a reaction temperature of 120 °C resulted in the highest yields. The catalyst showed excellent activity with a wide range of aryl halides and aryl acetylenes in the Sonogashira reaction. The use of a low catalyst loading further highlighted its efficiency. Moreover, the catalyst demonstrated noteworthy reusability by consistently preserving its activity and stability through seven successive runs. The magnetic properties of the catalyst allowed for easy separation and recovery.