Abstract
Advances in bottom-up material design have been significantly progressed through DNA-based approaches. However, the routine integration of semiconducting properties, particularly long-range electrical conduction, into the basic topological motif of DNA remains challenging. Here, we demonstrate this with a coordination polymer derived from 6-thioguanosine (6-TG-H), a sulfur-containing analog of a natural nucleoside. The complexation reaction with Au(I) ions spontaneously assembles luminescent one-dimensional helical chains, characterized as {AuI(μ-6-TG)}n, extending many μm in length that are structurally analogous to natural DNA. Uniquely, for such a material, this gold-thiolate can be transformed into a wire-like conducting form by oxidative doping. We also show that this self-assembly reaction is compatible with a 6-TG-modified DNA duplex and provides a straightforward method by which to integrate semiconducting sequences, site-specifically, into the framework of DNA materials, transforming their properties in a fundamental and technologically useful manner.
Highlights
Advances in bottom-up material design have been significantly progressed through DNA-based approaches
We show that the sulfur-containing analog of a natural nucleoside, 6-thioguanosine (6TG-H) reacts with gold(I) ions to spontaneously assemble luminescent helical chains that are structurally analogous to DNA
For such a material, this gold-thiolate coordination polymer can be transformed into a wire-like conducting form. We show that this self-assembly reaction is compatible with a 6-TG-modified DNA duplex and provides a straightforward method by which to integrate semiconductive domains, site-into DNA materials
Summary
Advances in bottom-up material design have been significantly progressed through DNA-based approaches. Modified bases, termed ligandosides, capable of providing specific, non-natural, metal-ion-binding modes have been incorporated into duplex DNA as a means of introducing new properties[30,31,32,33,34,35,36,37,38] While elegant these approaches are synthetically demanding, and, to date, none provide the extended, delocalized, bonding suited for effective electrical conductivity. We show that the sulfur-containing analog of a natural nucleoside, 6-thioguanosine (6TG-H) reacts with gold(I) ions to spontaneously assemble luminescent helical chains that are structurally analogous to DNA For such a material, this gold-thiolate coordination polymer can be transformed into a wire-like conducting form. We show that this self-assembly reaction is compatible with a 6-TG-modified DNA duplex and provides a straightforward method by which to integrate semiconductive domains, site-into DNA materials
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