Abstract

Caloric dietary restriction prolongs life span in a variety of organisms, and in mammals, the resultant lowering of core body temperature has been offered as one potential explanation. Conti et al . generated transgenic mice that overexpress mitochondrial uncoupling protein 2 in hypocretin-producing neurons within the hypothalamus, which lowers core body temperature by about 0.5ºC. In the absence of caloric restriction, the median life span of these "cool mice" was about 15% greater than that of their wild-type littermates. B. Conti, M. Sanchez-Alavez, R. Winsky-Sommerer, M. C. Morale, J. Lucero, S. Brownell, V. Fabre, S. Huitron-Resendiz, S. Henriksen, E. P. Zorrilla, L. de Lecea, T. Bartfai, Transgenic mice with a reduced core body temperature have an increased life span. Science 314 , 825-828 (2006). [Abstract] [Full Text] C. B. Saper, Life, the universe, and body temperature. Science 314 , 773-774 (2006). [Abstract] [Full Text]

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