A conversation with Rudolf Jaenisch.

Abstract

Rudolf Jaenisch of the Whitehead Institute at MIT is a remarkable scientist at the center of the study of epigenetics. Jaenisch (Figure 1) created the very first transgenic mice and did the first experiment showing that therapeutic cloning could correct a genetic defect. He also conducted the first proof of principle experiments with induced pluripotent stem (iPS) cells to correct sickle cell anemia and Parkinson disease in rodents. Hear more of his stories about his first scientific experiments, how to effectively mentor trainees, and his views on the ethics of stem cell use on the JCI website at http://www.jci.org/videos/cgms