Abstract
The syntheses of three trisaccharides: α-Neu5Ac-(2→3)-β- d-Gal-(1→4)-β- d-GlcNAc→OMe, α-Neu5Ac-(2→3)-β- d-Gal6SO 3Na-(1→4)-β- d-GlcNAc→OMe, and α-Neu5Ac-(2→3)-β- d-Gal-(1→3)-α- d-GalNAc→OBn were accomplished by using either methyl (phenyl 5-acetamido-4,7,8,9-tetra- O-acetyl-3,5-dideoxy-2-thio-β- d- glycero- d- galacto-2-nonulopyranoside)onate or methyl (phenyl N-acetyl-5-acetamido-4,7,8,9-tetra- O-acetyl-3,5-dideoxy-2-thio-β- d- glycero- d- galacto-2-nonulopyranoside)onate as the sialyl donor. The N, N-diacetylamino sialyl donor appears to be more reactive than its parent acetamido sugar when allowed to react with an disaccharide acceptor under the same glycosylation conditions. The trisaccharides, as well as the intermediate products, were fully characterized by 2D DQF 1H– 1H COSY and 2D ROESY spectroscopy.
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