A convergent fabrication of 7-ethyl-10-hydroxycamptothecin (SN-38)-loaded cobalt ferrite nanocarrier delivery for lung treatment

Abstract

The most common cancer-related death is lung cancer, especially non-small cell lung cancer (NSCLC). The low response and survival rates show the inability to treat NSCLC with existing medications effectively. This investigation aimed to establish a new method based on biocompatible cobalt ferrite (CFNPs) nanoformulation utilizing poly(d,l-lactide-co-glycolic) acid and oleic acid with the delivery of 7-Ethyl-10-hydroxycamptothecin (SN-38) for the treatment of lung cancer cells. The hydrothermal technique synthesized the CFNPs, which were then conjugated with SN-38 in a PLGA matrix. The CFNPs were then thoroughly characterized utilizing FTIR, XRD, TGA, FE-SEM, TEM, and DLS analyses. The cellular uptake, cytotoxicity, in vitro drug release, and drug loading were all assessed using the nanoparticles. The CFNPs had excellent crystallinity and were ferromagnetic, with a particle diameter of ~22 nm. The drug loading efficiency for the SN-38-loaded CFNPs (SN-38@CFNPs) was 81.9%, with a sustained SN-38 release over time of 8.5%. In A549 and H1299 lung cancer cells, effective internalization and anti-proliferative efficiency were reported. The morphological changes of the lung cancer cell (A549 and H1299) were examined by the acridine orange/ethidium bromide (AO/EB) and nuclear (DAPI) staining methods. The opportunity for promising SN-38 delivery for lung cancer to treat with the SN-38@CFNPs.