Abstract
A seco-precursor of macrolactin A was synthesized by coupling two advanced segments. Wittig reaction and Horner–Emmons reaction were utilized to construct the three characteristic E, Z and E, E dienes. The C 1–C 10 segment was synthesized through Horner–Emmons reaction with phosphonate reagent. The α-alkylation of sulfone stabilized anion with allyl bromide followed by desulfonation gave the C 11–C 24 segment.
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