Abstract
Alkylation of 4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine- 5-carbonitrile (1) gave the S-alkyl derivatives (2b,c). Compound (2c) could be cyclised into 3-methyl-5-oxo-5H-7- phenylthiazolo[ 3,2-a] pyrimidine-6-carboxamide (3). Further substitution of compounds (2a,b) yielded the N3-Substituted pyrimidine derivatives (7a-e). Desulphunisation of each of compounds (2a,b) with benzhydrazide resulted in the formation of 2-(2-benzoylhydrazino)- pyrimidine derivative (9) , which could be converted into the triazolo[4,3-a] pyrimidine (11). Each of compounds (2a,b) reacted with semicarbazide to produce directly the dioxotriazolopyrimidine derivative (14). Treatment of the 2-hydrazinopyrimidine derivative (10) with chloroacetyl chloride afforded the pyrimido[2,1-c]triazine derivative (16). Its isomeric compound (17) could be also prepared. The structures of the newly synthesized compounds were proved by chemical routes and spectral studies.
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