A convenient synthesis of enantiomerically pure ( R)-mexiletine using hydrolytic kinetic resolution method

Murugesan Sasikumar,Milind D Nikalje,Murugan Muthukrishnan

doi:10.1016/j.tetasy.2009.11.014

A convenient synthesis of enantiomerically pure ( R)-mexiletine using hydrolytic kinetic resolution method

Murugesan Sasikumar, Milind D Nikalje + Show 1 more

https://doi.org/10.1016/j.tetasy.2009.11.014

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Journal: Tetrahedron: Asymmetry	Publication Date: Dec 1, 2009
Citations: 24

Affiliation: Savitribai Phule Pune University, National Chemical Laboratory

#High Enantiomeric Purity #Kinetic Method + Show 7 more

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Abstract

Enantiopure ( R)-mexiletine was prepared in a simple and practical way using hydrolytic kinetic resolution method of terminal epoxide by Jacobsen’s catalyst. High enantiomeric purity (98% ee) was achieved and the method is well amenable to industrial scale-up.

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