Abstract
AbstractA convenient method for oxidation of allylic alcohols to the corresponding carboxylic acids is described. A two phase (methylene chloride/aqueous) silver oxide oxidation circumvents isolation of the intermediate aldehydes, thus making the procedure well suited to microscale carbon‐14 synthesis. Although we required a mixture of cis/trans‐3‐chloro‐acrylic acid‐UL‐14C and thus began the preparation with cis/trans‐3‐chloroallyl alcohol‐UL‐14C, the reaction sequence can be carried out starting with either isomer to provide the isomerically pure carboxylic acids.
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