Abstract
Several N,N-diformylaminomethyl ketones were prepared by treating the respective bromomethyl ketone with sodium diformylamide in acetonitrile at room temperature. This reaction produced N-formylaminomethyl ketones (I) when ethanol was used as the solvent. One of the formyl groups of N,N-diformylaminomethyl ketones was selectively removed by using a catalytic amount of sodium or potassium hydroxide in alcohol to the corresponding N-formylaminomethyl ketones I. The formyl groups of both N,N-diformyl- und N-formylaminomethyl ketones could be easily removed by either 5 % hydrochloric acid in ethanol or 6 N hydrochloric acid to give the corresponding aminomethyl ketone hydrochlorides .These reactions are general and give high yield of the products
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