A Convenient Synthesis of 2-Arylbenzo[b]furans from Aryl Halides and 2-Halophenols by Catalytic One-Pot Cascade Method

Abstract

The development of a multicatalytic one-pot synthesis of 2-arylbenzofurans starting from aryl halides and 2-halophenols is described. The protocol involves two Sonogashira coupling reactions, followed by 2-ethynylphenol cyclization leading to 2-arylbenzofuran derivatives. The process occurs smoothly under mild conditions, giving products in good yields, and can be applied to many 2-arylbenzofurans substituted both at 2-aryl position and in the benzodifuran moiety. Substituents such as halogens, hydroxyl, cyano, nitro, and amino groups are tolerated, enabling further functionalization of the system.