Abstract
ABSTRACT 2-Methyl-8-quinoline carboxylic acid 1 was readily synthesized by the improved Doebner–Miller reaction using anthranilic acid and crotonaldehyde in a two phase system containing 5 mol% PTC. By alkylation of methyl group in 1, other 2-alkyl-8-quinoline carboxylic acids (2a and 2b) have been easily prepared.
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