Abstract
Abstract 2 β ,3 α -Dihydroxyurs-12-en-28-oic acid ( 6 ) is a naturally occurring diastereoisomer of corosolic acid with glycogen phosphorylase inhibitory activity. A new strategy for the semi-synthesis of 6 was developed. Using the commercially available ursolic acid ( 1 ) as the starting materials, 6 was synthesized through five facile reactions with a high stereoselectivity and an overall yield of 47.3%. The structure of 6 was confirmed by optical rotation, ESI-MS, 1 H NMR and 13 C NMR data.
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