Abstract
A convenient synthesis of 1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine (1) is described. The condensation of tryptamine (2) with diethyl (2-formylethyl) malonate (3a), followed by treatment with alkali, gave the lactam ester (5a). Decarbethoxylation of 5a with LiCl-H2O-Me2SO afforded the lactam (8a), which was reduced with LiAlH4 to give the indoloquinolizine (1). The lactam (8b) which has an ethyl group at C3 was prepared from tryptamine (2) and diethyl ethyl (2-formylethyl) malonate (3b) instead of 3a.
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