Abstract
Synthesis of novel α-aminophosphonic acid esters (5a-n) were achieved with high yields through one-pot three component reaction process by Kabachnik-Fields reaction. It involves the reaction among amino acids/esters, substituted aromatic aldehydes and dialkyl phosphites in absolute ethanol at reflux temperature. Their structures were established by elemental analysis IR,¹H,¹³C,³¹P NMR and mass spectral data. All the title compounds were screened for their antibacterial activity. Most of the compounds exhibited moderate antimicrobial activity.
Highlights
Kabachnik-Fields reaction[1] is used for the synthesis of α-amino phosponic acid esters which have useful properties[2]
To the best of our knowledge, amino acid esters / acids were not used in the synthesis of α-amino phosphonates
We have used for the first time successfully and synthesized a series of novel α-amino phosphonates containing amino acids / esters under mild conditions without using any catalyst in high yields[17] Antibacterial activity is evaluated for the title compounds
Summary
Kabachnik-Fields reaction[1] is used for the synthesis of α-amino phosponic acid esters which have useful properties[2]. Classical approach to their synthesis is the Kabachnik-Fields reaction, which is a one-pot three component[14,15,16] operation involving amino acid ester, aldehyde and dialkyl phosphite. We have used for the first time successfully and synthesized a series of novel α-amino phosphonates containing amino acids / esters under mild conditions without using any catalyst in high yields[17] Antibacterial activity is evaluated for the title compounds.
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