Abstract
The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protein amino acids.Electronic supplementary materialThe online version of this article (doi:10.1007/s00726-011-1055-3) contains supplementary material, which is available to authorized users.
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