A controlled trial comparing human plasma protein fraction with freeze-dried plasma for resuscitation during the burn shock period

Abstract

A controlled trial was conducted comparing the use of freeze-dried plasma (FDP) with human protein fraction (HPPF) in the resuscitation of patients during the burn shock period. Twenty-four children and 13 adults were studied during the first week post burn. It was found that those who received HPPF tended to have depressed globulin levels: the immunoglobulin levels were depressed, the prothrombin time was prolonged and the fibrinogen level was also transiently decreased. In contrast those who received FDP had raised immunoglobulin levels and the prothrombin time was shortened. The incidence of septicaemia was markedly greater during the first week if HPPF was used. The differences between the two solutions were most marked in the more extensive burns. Although the physical properties of HPPF enable it to suffice as a plasma expander, it lacks certain physiological properties of FDP. The superiority of FDP over HPPF in the resuscitation of major burns is emphasized.