A controlled study on the effect of injected water-miscible retinyl palmitate on plasma concentrations of retinol and retinol-binding protein in children with measles in northern Nigeria.

Abstract

Post-measles corneal ulceration resembling keratomalacia is frequently seen in young children in northern Nigeria. The concentration of retinol in plasma has been found to be depressed more by measles than by malnutrition. In order to determine whether this could be due to a specific influence of measles on the uptake, storage and release of retinol by the liver or its subsequent transport in the plasma, retinyl ester was administered parenterally to assess its effect on the concentration of circulating holo retinol-binding protein. A water-miscible preparation of retinyl palmitate was administered by intramuscular injection to well- and malnourished children with and without acute measles. In all cases, the concentration of both retinol and retinol-binding protein rose appreciably with 24 h of administration of the vitamin preparation. Thus the failure of post-measles corneal lesions to respond to orally or parenterally administered vitamin A would not appear to be due to the inability of such vitamin A to increase the level of circulating retinal in the plasma of children with measles.