Abstract
Limited uncontrolled studies in the past have yielded conflicting results as to the ability of corticosteroids to suppress the immediate wheal-and-flare test. This double-blind controlled study, using 15 atopic volunteers, demonstrated that a one-week course of steroids exerted no significant effect, compared to placebo, on reactivity to ragweed wheal size and the threshold dilution measurements. Reactivity to compound 48–80 and histamine was also unaffected. In vivo effects of the steroid in these subjects was demonstrated by significant eosinopenia.
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