Abstract
IN RECENT years the whole field of skull base surgery, formerly a no-man's-land, has come increasingly into the foreground. Research and development in the field of narcosis, together with the use of antibiotics and replacement hormonal therapy and the development and use of the operating microscope, have provided the surgeon with better aids for operation and postoperative care. These have made possible a new look at the approach to the pituitary from below. The risk of infection, earlier one of the chief objections, is regarded to have decreased to a negligible level as a result of new therapeutic resources and surgical refinements as application of the septal mucosal flap to seal the sella-sphenoid dehiscence. Hypophysectomy has been utilized as palliation for metastatic carcinoma of the breast and prostate. There is increasing evidence that intractable diabetes with progressive retinopathy is benefited by this procedure. Also, malignant exophthalmos has responded to hypophysectomy,
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