Abstract
The purpose of this study was to investigate the thermal-induced solid-state characterization of metoclopramide hydrochloride monohydrate (MCP H2O) by using a combination of differential scanning calorimetry (DSC) and Fourier-transform infrared (simultaneous DSC-FTIR) microspectroscopy. The DSC and thermogravimetric (TG) analyses were also carried out. The result indicates that a continuous process of dehydration, amorphization and recrystallization for MCP H2O in the solid state was easily evidenced via the thermal responsive IR spectral changes by using this simultaneous DSC-FTIR microspectroscopy. In the heating course, one mole of water was first dehydrated from the MCP H2O sample beyond 77 °C, was then quickly transformed to an amorphous form due to the appearance of weak broad IR bands, and continuously recrystallized from 148 °C by showing the sharp IR bands. This one-step novel simultaneous DSC-FTIR microspectroscopy might be available for studying the changes in the progressive processes of the thermal-dependent solid-state characterizations of drugs.
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