Abstract
BT1062 from Bacteroides thetaiotaomicron is a homolog of Mfa2 (PGN0288 or PG0179), which is a component of the minor fimbriae in Porphyromonas gingivalis. The crystal structure of BT1062 revealed a conserved fold that is widely adopted by fimbrial components.
Highlights
The Gram-negative anaerobic bacterium Bacteroides thetaiotaomicron is a predominant member of the mammalian intestinal microbiota
We report the 2.2 Acrystal structure of a putative fimbrial assembly protein BT1062 from B. thetaiotaomicron, which was determined using the high-throughput pipeline of the Joint Center for Structural Genomics (JCSG; Lesley et al, 2002) as part of the National Institute of General Medical Sciences Protein Structure Initiative (PSI; http://www.nigms.nih.gov/Initiatives/PSI/)
At least four paralogs are found in B. thetaiotaomicron VPI-5482 (BT1062, BT2657, BT4225 and BT4226; sequence identity of >20%), three in Porphyromonas gingivalis (PGN0185, PGN0288 and PGN0289) and eight in B. fragilis NCTC 9343 (BF1578, BF1851, BF1976, BF2185, BF2264, BF2871, BF3328 and BF4229)
Summary
The Gram-negative anaerobic bacterium Bacteroides thetaiotaomicron is a predominant member of the mammalian intestinal microbiota. It is important for the study of the symbiotic relationship between bacteria and humans, as well as for its abilities to digest complex plant polysaccharides and host-derived polysaccharides (Xu et al, 2003). It is an opportunistic pathogen and can cause serious infections. The BT1062 gene of B. thetaiotaomicron encodes a predicted lipoprotein with a molecular weight of 36 535 Da (residues 1–317) and a calculated isoelectric point of 4.8
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