Abstract
The chemokine receptor subtype CXCR4 belongs to the G-protein coupled receptors (GPCRs) and is, together with itsnatural ligand CXCL12 (or SDF-1), a central part of thesignaling system in the human body. Its functions range fromstem-cell trafficking during embryogenesis, through cardio-vascular, hematopoietic, and brain development, to signalingin the nervous and immune system.
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