Abstract
AbstractA highly efficient (10.1 % overall yield) and convergent (longest linear sequence of 16 steps) synthesis of mupirocin H has been achieved, starting from commercially available (+)‐(R)‐Roche ester. The route relies on an efficient Grubbs cross‐metathesis reaction to generate a key, late‐stage E‐olefin intermediate, and a cobalt‐catalysed diastereoselective Reformatsky reaction to produce a β‐hydroxy ester that serves as a late‐stage intermediate.
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