Abstract
A concise approach to partially saturated fused tricyclic pyrrolo[3,2-d]pyrimidines has been developed. Herein, we report a three-step route to the core templates, starting with a Sonogashira coupling and utilising either a CuI-catalysed or base-mediated 5-endo-dig cyclisation to form the pyrrolopyrimidine ring, followed by Mitsunobu cyclisation to afford the tricyclic system. This method facilitates synthetic access to a structural class with limited representation in the literature and is amenable to further elaboration by virtue of a halide incorporated at the 4-position.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
