Abstract
Long intergenic non-protein coding RNA 324 (LINC00324) is an example of lncRNAs whose roles in the carcinogenesis is being elucidated. This lncRNA is encoded by a gene located on 17p13.1. It has been shown to be over-expressed in a variety of cancer cell lines and tumoral tissues. However, there are few reports showing down-regulation of LINC00324 in cancer cell lines and tissues. miR-615-5p/AKT1, miR-139-5p/IGF1R, miR-769-5p/STAT3, miR-3200-5p/BCAT1 and miR-214-5p/CDK6/CCND1/MDM2/MDM4 are examples of miRNA/mRNA axes being influenced by LINC00324. LINC00324 can be regarded as a promising candidate for development of diagnostic and prognostic panels. Moreover, it can be used a therapeutic target for a wide range of cancers. The current review summarizes the evidence regarding the impact of lINC00324 in the carcinogenic processes.
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