Abstract

Reaction of ( R)-phenylglycinol with racemic methyl 4-formylhexanoate takes place with a remarkable stereoselectivity to give two diastereomeric 6-ethyloxazolopiperidones (9:1 ratio) in 76% overall yield. After LiAlH 4 reduction and catalytic hydrogenation, the major isomer was converted to ( S)-3-ethylpiperidine.

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